Supermidine™ : Natural spermidine, for you and your cells.

Supermidine™ is Shanghai Aidu Biotech's bio-perfected form of Wheat Germ Extract Spermidine.

Supermidine™ is a naturally occurring molecule that is vital to cell function and survival. It’s part of a group of molecules called polyamines. Declining polyamine levels are associated with inflammation-driven aging. Their levels decline continuously with age and Supermidine™ supplementation increases life span in model organisms. (1.2.3.)
Supermidine™ has the unique ability to activate autophagy, a powerful anti-aging process that lowers systemic inflammation & preserves NAD⁺ levels.

Meet Supermidine™ Wheat Germ extract Spermidine :

Wheat Germ

Spermidine 0.2%
Spermidine 0.5%
Spermidine 1%

Triticum aestivum

2 years

Light Yellow to Yellow Fine


Supermidine™ Benefits:
Supermidine™ Induces Autophagy and Reduces Inflammation
Spermidine’s main mechanism of action is its ability to induce autophagy, a self-preservation process which clears out toxic, damaged and dysfunctional cells, resulting in lower levels of inflammation in the body. 3

(Mechanism Of Autophagy)

Supermidine™ for anti-aging and Longevity
Internally, Supermidine™ has been seen to stabilise mitochondrial DNA, which can protect against aging caused by mutations in the mitochondria genome.
Supermidine™ levels decrease with age. Spermidine supplementation can replenish these levels and induce autophagy, thus renewing cells and extending lifespan. 2

Supermidine™ for human hair growth
It improves the physical signs of aging by promoting thicker hair growth, longer eyelashes, stronger nails and more youthful skin achieved through keratin growth.

Supermidine™ for cognition
Animal studies have shown that spermidine can penetrate the blood-brain barrier and improve cognition in mice. 4

1. Minois N, Carmona-Gutierrez D, Madeo F: Polyamines in aging and disease. Aging 2011;3:716-732.
2.Pucciarelli S, Moreschini B, Micozzi D, De Fronzo GS, Carpi FM, Polzonetti V, Vincenzetti S, Mignini F, Napolioni V: Spermidine and spermine are enriched in whole-blood of nona/centenarians. Rejuv Res 2012;15:590-595.
3. Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F: Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 2009;11:1305-1314.
4. Schroeder , Sebastian J. Hofer , Andreas Zimmermann , Raimund Pechlaner, Christopher Dammbrueck , Tobias Pendl , G.Mark Marcello , Viktoria Pogatschnigg , Martina Bergmann , Melanie Müller , Verena Gschiel , Selena Ristic , Jelena Tadic , Keiko Iwata , Gesa Richter , Aitak Farzi , Muammer Üçal , Ute Schäfer , Michael Poglitsch , Philipp Royer …Frank Madeo:Dietary spermidine improves cognitive function. Volume 35, Issue 2, 13 April 2021, 108985