Calcium Alpha Ketoglutarate (CA-AKG)

Calcium Alpha Ketoglutarate (Ca-AKG) is a natural bioactive compound, serving as the calcium salt form of endogenous α-ketoglutarate (AKG). It ingeniously integrates the core metabolic regulatory function of the tricarboxylic acid (TCA) cycle with the bone-nourishing benefits of calcium.

Core Distinctions: Ca-AKG vs AKG

Although α-ketoglutarate (AKG) is a central substance in mitochondrial energy metabolism, its calcium salt form (Ca-AKG) boasts significant advantages as an application ingredient:

Greater Stability: AKG is prone to moisture absorption, heat-sensitive, and strongly acidic. In contrast, Ca-AKG exhibits extremely stable physical properties with a neutral pH (6.0-8.0). This makes it easier to store and gives it superior flowability during tableting or capsule filling.

Superior Biocompatibility: Ca-AKG is less irritating to the digestive tract, avoiding gastrointestinal discomfort that may be caused by strongly acidic substances, and demonstrates excellent bioavailability.
Dual Metabolic Benefits: Ca-AKG not only supplies key metabolic intermediates but also simultaneously provides a highly bioactive calcium source. Research has confirmed that this combination possesses stronger synergistic effects compared to AKG alone in supporting longevity signaling pathways (such as delaying DNA methylation-related aging).
As a dual-function active ingredient, Ca-AKG has become a premium choice in the global health industry for products targeting metabolic regulation, anti-aging, and mineral supplementation.

Product Description

Appearance: White or off-white powder

Solubility: Easily soluble in water, alcohols, ketones and other solvents
CAS Number: 71686-01-6
Molecular Weight: 184.16
Molecular Formula: C₅H₄CaO₅
pH Value: 6-8
Calcium Content: 18-21%

---

Product Specifications

Product Process and Advantages

· Green Biosynthesis, Safe and Residue-Free: We employ bio-fermentation technology combined with precise calcium salt complexation processes, replacing traditional chemical synthesis at the source to achieve genuine "green production":

Pure Source: Thoroughly eliminates heavy metal residues and by-product contamination, ensuring the product has excellent biocompatibility.

Full-Chain Control: From strain selection, fermentation, to drying and crystallization, the entire process strictly adheres to GMP standards.

International Authoritative Certification: Has passed FSSC22000, HALAL, and KOSHER certifications, with quality meeting the access standards of multiple regions worldwide.

· High Purity and High Activity, Quality Aligned with International Standards: Relying on multi-stage purification technology, the Ca-AKG provided by Aidu demonstrates extremely high biological activity:

Core Indicators: The main component content is no less than 98%, and the calcium content is precisely controlled at 18-21%.

Physicochemical Properties: With a pH value in the range of 6-8 (neutral to weakly alkaline), it has outstanding stability and is easy for long-term storage.

High Utilization Rate: The active ingredients can quickly act on target organs such as bones and muscles, with bioavailability exceeding that of single AKG.

· Diverse Application Scenarios and Strong Formula Compatibility: As a white/off-white powder, Ca-AKG has extremely high production adaptability. Its property of being slightly soluble in water meets the R&D needs of solid preparations such as capsules, tablets, and powders; it can be synergistically combined with various functional ingredients like vitamins, collagen, and amino acids without compatibility contraindications; it can meet the concentration, solubility, and functional requirements of different fields such as dietary supplements, sports nutrition, functional foods, and animal health, providing sufficient flexibility for formula development.

· Prominent Cost Advantages and Excellent Cost-Effectiveness: Compared with single anti-aging or calcium-supplementing ingredients, Ca-AKG offers a more cost-effective solution:

Integrated Efficacy: Achieves the dual effects of "metabolic regulation + mineral supplementation" within a single ingredient.

Stable Supply: Relying on a mature industrialization base, it ensures stable production capacity and significantly reduces customers' R&D and investment costs.

Product Functions and Mechanisms

Empowered by Slow-release Technology, Delivering Superior Bioavailability

Unlike ordinary AKG, Ca-AKG (Calcium Alpha Ketoglutarate) possesses a natural slow-release property. Its molecular structure enables the steady and gradual release of active ingredients in the intestine, effectively preventing drastic fluctuations in blood drug concentrations.

• Mechanism of Action :It extends the circulation time of active ingredients in the body, ensuring that cells can continuously take up α-ketoglutarate, and its bioavailability significantly outperforms traditional forms.

Reversing Biological Age, Initiating Deep Epigenetic Regulation

Ca-AKG is one of the few substances currently clinically verified to intervene in the "biological clock".

*Research data indicates that Ca-AKG (Calcium α-ketoglutarate), through metabolic regulation,

can effectively exert anti-aging effects and significantly extend healthspan.

• Scientific Evidence: Animal experiments published in top journals such as Cell Metabolism and Aging Cell, as well as the Rejuvenation clinical study, have confirmed that Ca-AKG, as a core cofactor of TET enzymes, can reset the epigenetic markers associated with aging by precisely regulating the DNA methylation pattern.

• Efficacy Outcomes: Animal experiment results showed that the epigenetic age of mice in the intervention group decreased by an average of 9.2 months, the median lifespan was extended by 9.6%-19.7%, and the frailty index was significantly reduced.

Activating Cellular Autophagy for In-depth Mitochondrial Cleanup

Ca-AKG serves as a potent inducer of cellular autophagy, capable of initiating the body's innate "cleanup mechanism."

• Mechanism: By continuously stimulating autophagy (Autophagy), it accelerates the clearance of damaged proteins and dysfunctional mitochondria within cells, optimizes the cellular metabolic environment, and prevents functional decline caused by cellular aging.

Dual Metabolic Support: Building a Solid Defense for Muscles and Bones

Ca-AKG offers dual metabolic support for the elderly and sports enthusiasts.

• Muscle Strength and Endurance (Muscle Integrity): As a key intermediate in ammonia metabolism, Ca-AKG efficiently converts accumulated ammonia in the body to maintain nitrogen balance. It not only enhances athletic endurance but also demonstrates remarkable effectiveness in preventing age-related muscle atrophy (Sarcopenia).

• Bone & Joint Repair (Bone & Joint Resilience): Beyond supplementing calcium, Ca-AKG regulates the AMPK and mTOR pathways, activating autophagy in chondrocytes while suppressing inflammatory stress responses. With this multi-dimensional mechanism, it effectively alleviates joint degeneration, providing more comprehensive bone health protection for postmenopausal women and the elderly.

Typical Formulation Combinations

The current market trend has comprehensively shifted from "single-ingredient" to "multi-target synergy." Below are several popular formula combinations favored in 2026:

·Cellular Energy Comprehensive Formula: Ca-AKG + NMN (or NAD+ precursor)

NMN boosts the level of NAD+, which is responsible for energy production and DNA repair, while Ca-AKG optimizes the tricarboxylic acid cycle and suppresses inflammatory responses. Working together, they comprehensively enhance vitality and effectively alleviate fatigue caused by mitochondrial dysfunction.

·Biological Autophagy and Cleansing Formula: Ca-AKG + Spermidine + Fisetin

Spermidine induces cellular autophagy, Fisetin clears senescent cells (classified as a Senolytic), and Ca-AKG assists in removing damaged mitochondria. The trio collaborates to carry out a "deep clean-up," efficiently eliminating cellular waste and delaying organ function degeneration.

·Bone and Joint Strengthening Formula: Ca-AKG + Collagen Peptide + Vitamin D3/K2

Ca-AKG inhibits ferroptosis in chondrocytes, collagen provides structural support for bones and joints, and vitamin D3/K2 guides the precise deposition of calcium ions into bones. This formula is precisely tailored for patients with arthritis, those with reduced joint flexibility, and individuals with low bone density.

·Modern Metabolism and Blood Sugar Control Formula: Ca-AKG + Dihydroberberine

Together, they activate the AMPK pathway, optimize blood sugar metabolism, and improve insulin sensitivity, fundamentally preventing accelerated aging caused by metabolic disorders.

Applications

·Dietary Supplements and Health Foods: This is currently the core application area. Ca-AKG is recognized as an ingredient with stronger "systemic anti-aging" capabilities compared to ordinary calcium salts.

Biological Age Reversal: Targeting elites aged 35 and above, with the core selling point of "reversing biological age by 7-8 years".

Menopausal Health: For postmenopausal women, leveraging the synergistic effect of calcium ions to assist in preventing osteoporosis while alleviating metabolic slowdown.

·Sports Nutrition and Recovery

Prevention of Muscle Loss:Focusing on the middle-aged and elderly population to help prevent "sarcopenia".

Optimization of Ammonia Metabolism: Helping high-intensity athletes quickly metabolize accumulated blood ammonia, shortening the fatigue recovery period after exercise.

·Functional Skincare and Cosmetics (Emerging Field)

Skin Longevity: Aligning with the latest "biotechnology beauty" trend of 2026, it promotes collagen synthesis in the dermis through topical application to enhance skin elasticity.

Scalp Care:Studies have confirmed that AKG can protect hair follicle melanocytes. When applied in high-end skincare or hair care essences, it features the benefits of "preventing gray hair" and "anti-aging for the scalp".

·Pet Nutrition (Specialized Market): With the trend of pet aging, high-end pet brands have introduced Ca-AKG into the formulas for aging dogs and cats to boost vitality, improve coat health, and protect joints.

Packaging & Storage

Packaging Specifications: 1kg/aluminum foil bag, 5kg/aluminum foil bag, 10kg/aluminum foil bag, and 25kg/cardboard drum. Customized packaging specifications are available according to customer requirements.
Storage Conditions: Store in a sealed, light-proof, dry, and well-ventilated place. Keep away from high temperatures and humid environments, and avoid co-storage with toxic, harmful, or odorous substances.
Shelf Life: 24 months

Why Choose Us as Your CA-AKG Supplier

We are a professional manufacturer and supplier of high-purity CA-AKG raw materials, providing integrated R&D, production, and supply chain solutions for the global health industry:

Integrated R&D and Production:Backed by patented biosynthesis technology, we have established four core R&D platforms and support customized product specifications.

Stable Large-scale Supply:With mature industrial capacity, we ensure batch consistency and eliminate supply shortages.

Rigorous Quality Control:We hold international certifications (FSSC22000, Halal, Kosher), conduct full-chain inspections, and fully comply with global standards.

Customized Solutions: We offer formula design, dosage optimization, and technical support tailored to different application scenarios.

Global Export Experience:We have provided reliable supply to over 70 countries/regions, backed by professional logistics and after-sales services.

Competitive Pricing: Through vertical supply chain integration and cost optimization, we offer long-term stable pricing for cooperation.

We are committed to supplying our partners with premium CA-AKG raw materials, one-stop technical support, and long-term stable supply, empowering your product development and global market expansion to create greater value.

---

References:

[1] Shahmirzadi, A. A., et al. (2020). "Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice." Cell Metabolism, 32(3), 447-456.

[2] Demidenko, O., et al. (2021). "Rejuvenation of gene expression pattern of aged mice by Alpha-Ketoglutarate." Aging (Albany NY).

[3] Zeng, D., et al. (2021). "Alpha-Ketoglutarate supplementation decreased biological age in humans." Rejuvenation Research.

[4] Chin, R. M., et al. (2014). "The metabolite $alpha$-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR." Nature, 510(7505), 397-401.

[5] Wang, Y., et al. (2025/2026). "Mechanism of AKG in alleviating OA through AMPK-PGC-1$alpha$ signaling pathway." Frontiers in Molecular Biosciences (or relevant recent industry research).